Genes NMF_Filt Prospective IPMS Cancer Co-Regulation STRING Experimental Pathway Knowledge CCL5 213.5 0.0 0.0 0.0 0.0 ERG 210.5 0.0 0.0 0.0 0.0 CXCL9 172.5 0.0 0.0 0.0 0.0 CD4 168.5 0.0 0.0 0.0 0.0 FOXO1 164.5 0.0 1.0 0.0 0.0 PAX2 150.5 0.0 0.0 0.0 0.0 CCR7 149.5 0.0 0.0 0.0 0.0 CCL19 144.5 0.0 0.0 0.0 0.0 MSH2 142.5 1.0 0.0 0.0 0.0 CX3CL1 132.5 0.0 1.0 0.0 0.0 TLR2 130.5 0.0 0.0 1.0 0.0 CXCL12 123.5 0.0 0.0 0.0 0.0 CCL1 119.5 0.0 0.0 0.0 0.0 GATA2 115.5 0.0 0.0 0.0 0.0 MLH1 112.5 0.0 0.0 0.0 0.0 CDK2 105.5 1.0 0.0 0.0 0.0 IL4 91.5 0.0 0.0 0.0 0.0 FBXW7 90.5 0.0 0.0 0.0 0.0 MAGEA3 83.5 0.0 0.0 0.0 0.0 CASP8 73.5 0.0 0.0 0.0 0.0 ARID1A 67.5 0.0 0.0 0.0 0.0 CDX2 67.0 0.0 0.0 0.0 0.0 CCL2 61.5 0.0 0.0 0.0 0.0 NEDD4 60.5 0.0 1.0 0.0 0.0 CTLA4 57.5 0.0 0.0 0.0 0.0 FOXP3 54.5 0.0 0.0 0.0 0.0 VHL 53.5 0.0 0.0 0.0 0.0 CDKN1A 52.5 0.0 0.0 0.0 0.0 PAX6 52.5 0.0 0.0 0.0 0.0 ATM 48.5 0.0 0.0 0.0 0.0 AKT2 45.5 0.0 0.0 1.0 1.0 E2F1 36.0 0.0 0.0 1.0 0.0 ADAM10 32.0 0.0 1.0 0.0 0.0 FLT3 31.5 0.0 0.0 1.0 0.0 JAK1 30.5 0.0 1.0 1.0 0.0 HRAS 27.5 0.0 0.0 1.0 1.0 FGFR3 27.0 0.0 1.0 1.0 0.0 TLR4 25.0 0.0 0.0 1.0 0.0 DCN 24.5 0.0 0.0 1.0 0.0 STAT1 24.0 0.0 0.0 1.0 0.0 CDH2 23.5 0.0 0.0 0.0 0.0 NRG1 21.0 0.0 1.0 1.0 1.0 GRB10 20.5 0.0 0.0 1.0 0.0 MDM2 19.5 0.0 0.0 0.0 0.0 MUC2 19.5 0.0 0.0 0.0 0.0 CDK6 19.5 0.0 1.0 0.0 0.0 SMAD4 19.0 0.0 0.0 0.0 0.0 MAP2K2 18.5 0.0 0.0 1.0 1.0 TLR3 15.5 0.0 1.0 1.0 0.0 CXCL1 13.0 0.0 0.0 0.0 0.0 GSK3B 13.0 0.0 0.0 1.0 0.0 TIMP1 12.5 0.0 0.0 0.0 0.0 EPAS1 11.5 0.0 1.0 0.0 0.0 EGFR 9.0 0.0 0.0 0.0 0.0 CASP3 9.0 0.0 0.0 0.0 0.0 NRAS 8.0 0.0 0.0 1.0 1.0 SOX9 8.0 0.0 0.0 0.0 0.0 CXCR4 7.0 1.0 0.0 1.0 0.0 BAX 5.5 1.0 0.0 0.0 0.0 CXCL8 4.5 0.0 0.0 0.0 1.0 ENG 4.5 0.0 0.0 0.0 0.0 JAK2 3.5 0.0 0.0 1.0 0.0 ADAM17 1.0 0.0 1.0 0.0 0.0 HIF1A 1.0 0.0 1.0 0.0 0.0 KRAS 0.0 0.0 0.0 1.0 1.0 ERBB2 0.0 0.0 0.0 1.0 1.0 PTEN 0.0 0.0 0.0 0.0 0.0 STAT3 0.0 0.0 0.0 1.0 0.0 BRAF 0.0 0.0 0.0 1.0 0.0 TP53 0.0 0.0 0.0 1.0 0.0 VEGFA 0.0 0.0 1.0 0.0 0.0 PIK3CA 0.0 1.0 1.0 0.0 1.0 CCNB1 -0.5 0.0 0.0 0.0 0.0 EGF -1.0 0.0 0.0 1.0 1.0 AKT1 -1.0 0.0 0.0 1.0 1.0 TNF -1.5 0.0 0.0 0.0 0.0 MTOR -2.0 1.0 0.0 1.0 0.0 MYC -2.0 0.0 0.0 0.0 1.0 HBEGF -2.5 0.0 1.0 1.0 1.0 CTNNB1 -3.0 0.0 0.0 1.0 1.0 RET -4.0 0.0 0.0 1.0 0.0 ERBB3 -5.0 0.0 1.0 1.0 1.0 BCL2L1 -5.0 0.0 0.0 0.0 0.0 IL6 -5.0 0.0 0.0 0.0 0.0 CDK4 -5.0 0.0 0.0 0.0 0.0 STAT6 -5.5 0.0 0.0 1.0 0.0 PTK2 -6.0 0.0 0.0 1.0 1.0 MAP2K1 -6.0 0.0 1.0 1.0 1.0 ERBB4 -7.0 0.0 0.0 1.0 1.0 PTGS2 -7.0 0.0 1.0 0.0 0.0 BRCA1 -7.5 0.0 0.0 0.0 0.0 GRB2 -7.5 1.0 0.0 1.0 1.0 HLA-A -7.5 1.0 0.0 1.0 0.0 AREG -8.0 0.0 0.0 1.0 1.0 KDR -8.0 0.0 0.0 1.0 0.0 BIRC5 -9.0 0.0 0.0 0.0 0.0 CD274 -9.5 0.0 1.0 0.0 0.0 APP -10.5 0.0 1.0 1.0 0.0 CCND1 -11.0 0.0 0.0 1.0 0.0 MAPK1 -12.5 1.0 1.0 1.0 1.0 MUC5AC -12.5 0.0 0.0 0.0 0.0 MMP9 -13.0 0.0 0.0 0.0 0.0 ROS1 -14.0 0.0 1.0 0.0 0.0 CHEK1 -16.5 0.0 0.0 0.0 0.0 MMP2 -17.0 0.0 0.0 0.0 0.0 BTC -18.0 0.0 0.0 1.0 1.0 ABCG2 -20.0 0.0 1.0 0.0 0.0 SMARCB1 -20.0 0.0 0.0 0.0 0.0 IDH1 -22.0 1.0 0.0 0.0 0.0 HGF -22.0 0.0 0.0 0.0 0.0 SMAD3 -22.0 0.0 1.0 0.0 0.0 GLI1 -22.5 0.0 0.0 1.0 0.0 CBL -24.0 1.0 1.0 1.0 1.0 IL6ST -24.5 0.0 1.0 0.0 0.0 MSX1 -24.5 0.0 0.0 0.0 0.0 NOTCH1 -26.0 0.0 1.0 1.0 0.0 MGMT -28.5 0.0 1.0 0.0 0.0 CDKN1B -28.5 0.0 0.0 0.0 0.0 EIF4EBP1 -28.5 0.0 0.0 0.0 0.0 BCL2 -29.0 0.0 0.0 0.0 0.0 ACTA2 -29.5 0.0 0.0 1.0 0.0 FOXO3 -30.0 0.0 0.0 0.0 0.0 BRCA2 -30.5 0.0 0.0 0.0 0.0 GATA3 -31.0 0.0 0.0 0.0 0.0 CSK -33.0 0.0 0.0 1.0 0.0 CDH1 -33.0 0.0 0.0 1.0 0.0 ABCB1 -33.5 0.0 0.0 0.0 0.0 EREG -34.0 0.0 0.0 1.0 1.0 FGFR2 -35.5 0.0 1.0 1.0 0.0 STK11 -36.5 0.0 0.0 1.0 0.0 MUC16 -36.5 0.0 0.0 0.0 0.0 IGF1R -38.0 0.0 0.0 1.0 1.0 CD44 -38.0 0.0 0.0 0.0 0.0 AR -38.5 0.0 0.0 1.0 0.0 TP63 -39.5 0.0 0.0 0.0 0.0 SHC1 -39.5 1.0 0.0 1.0 1.0 TWIST1 -39.5 0.0 0.0 0.0 0.0 NOS2 -40.0 0.0 1.0 0.0 0.0 ERCC1 -41.0 0.0 0.0 1.0 0.0 FAS -41.5 0.0 0.0 1.0 0.0 SMAD2 -42.5 0.0 0.0 0.0 0.0 MUC1 -43.0 0.0 0.0 1.0 0.0 SNAI1 -43.5 0.0 0.0 0.0 0.0 PXN -44.5 0.0 0.0 1.0 0.0 TGFB1 -45.5 0.0 0.0 1.0 0.0 FGFR1 -46.0 0.0 0.0 0.0 0.0 EGR1 -48.5 0.0 0.0 1.0 0.0 TTF1 -49.5 0.0 0.0 0.0 0.0 PDCD1 -49.5 0.0 0.0 0.0 0.0 CLDN1 -49.5 0.0 1.0 0.0 0.0 BECN1 -50.0 0.0 0.0 1.0 0.0 ZEB1 -50.5 0.0 1.0 0.0 0.0 CXCL2 -50.5 0.0 0.0 0.0 0.0 SLC2A1 -51.0 0.0 1.0 0.0 0.0 CKAP4 -54.0 0.0 0.0 1.0 0.0 BMI1 -54.5 0.0 0.0 0.0 0.0 NKX2-1 -55.0 0.0 0.0 0.0 0.0 GPER1 -55.5 0.0 0.0 0.0 0.0 PROM1 -55.5 0.0 0.0 0.0 0.0 DNMT1 -55.5 0.0 0.0 0.0 0.0 ADAM12 -56.5 0.0 0.0 1.0 0.0 OCLN -56.5 0.0 0.0 0.0 0.0 RELA -58.5 0.0 0.0 0.0 1.0 RAC1 -60.5 1.0 0.0 1.0 1.0 H2AFX -61.5 0.0 0.0 1.0 0.0 PRKDC -61.5 0.0 0.0 0.0 0.0 CAV1 -63.5 0.0 1.0 1.0 0.0 MUC5B -63.5 0.0 0.0 0.0 0.0 CD24 -64.5 0.0 0.0 0.0 0.0 PTPN11 -65.5 1.0 1.0 1.0 0.0 SOS1 -68.5 1.0 0.0 1.0 1.0 LYN -68.5 1.0 0.0 1.0 0.0 CYP1A1 -69.5 0.0 0.0 0.0 0.0 HES1 -70.5 0.0 0.0 0.0 0.0 CTGF -72.5 0.0 0.0 1.0 0.0 ZEB2 -73.5 0.0 0.0 0.0 0.0 CXCL5 -74.0 0.0 1.0 0.0 0.0 YAP1 -75.0 0.0 1.0 1.0 0.0 HDAC1 -75.5 0.0 0.0 0.0 0.0 XIAP -76.5 0.0 0.0 0.0 0.0 TJP1 -80.0 0.0 1.0 1.0 0.0 MCL1 -80.5 0.0 0.0 0.0 0.0 RHOA -83.5 1.0 0.0 1.0 1.0 CYBB -83.5 0.0 0.0 0.0 0.0 LRIG1 -85.0 0.0 0.0 1.0 0.0 EZH2 -89.0 0.0 0.0 0.0 0.0 MMP1 -90.0 0.0 0.0 0.0 0.0 CYP2D6 -90.5 0.0 0.0 0.0 0.0 EPCAM -91.5 1.0 0.0 0.0 0.0 PARP1 -91.5 0.0 0.0 1.0 0.0 CASP7 -92.5 0.0 0.0 0.0 0.0 ATRX -94.5 0.0 0.0 0.0 0.0 ACKR3 -98.5 0.0 0.0 1.0 0.0 SOX2 -99.0 0.0 1.0 0.0 0.0 SPINK1 -100.5 0.0 0.0 0.0 0.0 HLA-G -100.5 0.0 0.0 0.0 0.0 CA9 -101.5 0.0 1.0 0.0 0.0 IKBKB -102.5 0.0 0.0 0.0 0.0 SYK -103.5 0.0 0.0 1.0 0.0 EML4 -109.5 1.0 0.0 0.0 0.0 NDRG1 -111.5 0.0 1.0 0.0 0.0 ERRFI1 -113.5 0.0 1.0 1.0 0.0 RRM1 -118.0 0.0 0.0 0.0 0.0 HNF4A -118.5 0.0 0.0 0.0 0.0 MMP7 -120.0 0.0 0.0 0.0 0.0 FCGR3B -121.5 0.0 0.0 0.0 0.0 HDAC6 -124.5 0.0 0.0 1.0 0.0 ACVRL1 -126.5 0.0 0.0 0.0 0.0 NFE2L2 -127.5 0.0 1.0 0.0 0.0 CYLD -127.5 0.0 0.0 0.0 0.0 PML -128.5 0.0 0.0 1.0 0.0 IGFBP3 -130.0 0.0 0.0 1.0 0.0 SHH -131.0 0.0 0.0 0.0 0.0 CD47 -138.5 0.0 0.0 0.0 0.0 WWOX -139.5 0.0 0.0 0.0 0.0 JAG1 -141.5 0.0 1.0 0.0 0.0 FCGR3A -142.0 0.0 0.0 0.0 0.0 TOP2B -144.5 1.0 0.0 0.0 0.0 CREB1 -149.0 0.0 0.0 0.0 0.0 GAB1 -150.0 1.0 0.0 1.0 0.0 SERPINE1 -156.5 0.0 1.0 0.0 0.0 MMP13 -160.5 0.0 0.0 0.0 0.0 MVP -161.5 0.0 0.0 1.0 0.0 YY1AP1 -169.5 0.0 0.0 0.0 0.0 ICAM1 -171.5 0.0 0.0 1.0 0.0 PTPN1 -173.5 1.0 0.0 1.0 0.0 KRT5 -174.0 0.0 0.0 1.0 0.0 SMO -180.5 0.0 0.0 0.0 0.0 NES -182.0 1.0 0.0 0.0 0.0 FOXA2 -182.5 0.0 0.0 0.0 0.0 CDKN2B -183.5 0.0 0.0 1.0 0.0 SPRY2 -184.5 0.0 0.0 1.0 0.0 CDKN2A -189.5 0.0 0.0 1.0 0.0 PAK1 -190.5 0.0 0.0 1.0 0.0 HMOX1 -192.5 0.0 0.0 0.0 0.0 PRKCA -196.5 0.0 1.0 1.0 1.0 S100A4 -205.5 0.0 0.0 1.0 0.0 SDC1 -209.5 0.0 0.0 0.0 0.0 INSR -210.5 1.0 0.0 1.0 0.0 PRKCD -211.5 1.0 1.0 1.0 0.0 PTCH1 -215.5 0.0 0.0 1.0 0.0 USP8 -216.0 0.0 0.0 1.0 0.0 YBX1 -216.5 1.0 0.0 0.0 0.0 SDC4 -219.5 0.0 0.0 0.0 0.0 WWTR1 -223.5 0.0 1.0 0.0 0.0 KEAP1 -224.5 0.0 0.0 1.0 0.0 CRKL -231.5 0.0 1.0 1.0 0.0 KLRK1 -235.5 0.0 0.0 0.0 0.0 TGFA -236.5 0.0 1.0 1.0 1.0 OLIG2 -236.5 0.0 0.0 0.0 0.0 NAPSA -236.5 0.0 0.0 0.0 0.0 BSG -239.5 0.0 0.0 0.0 0.0 ORAI1 -240.5 0.0 0.0 0.0 0.0 CIP2A -241.5 0.0 0.0 1.0 0.0 TUBB3 -241.5 0.0 0.0 0.0 0.0 AURKA -243.5 1.0 0.0 1.0 0.0 HTATIP2 -244.5 0.0 0.0 0.0 0.0 EGLN3 -245.5 0.0 1.0 0.0 0.0 FASN -252.5 0.0 0.0 0.0 0.0 TFE3 -257.5 0.0 1.0 0.0 0.0 VPS37A -258.5 0.0 0.0 0.0 0.0 REG4 -259.5 0.0 0.0 0.0 0.0 ARRB2 -259.5 0.0 0.0 1.0 0.0 MTHFR -260.5 0.0 0.0 0.0 0.0 MCAM -265.5 0.0 0.0 0.0 0.0 PIK3R1 -266.5 1.0 0.0 1.0 1.0 EPGN -267.5 0.0 0.0 0.0 0.0 KIF5B -270.5 0.0 0.0 0.0 0.0 PLCG1 -271.5 0.0 0.0 1.0 1.0 CD82 -274.5 0.0 1.0 1.0 0.0 CHI3L1 -277.5 0.0 0.0 0.0 0.0 APPL1 -280.5 1.0 0.0 1.0 0.0 TACC3 -281.5 0.0 0.0 0.0 0.0 DUSP1 -282.5 0.0 1.0 0.0 0.0 ITGB3 -286.5 1.0 0.0 1.0 0.0 LAMP1 -289.5 1.0 0.0 1.0 0.0 TRPM6 -290.5 0.0 0.0 0.0 0.0 SH3KBP1 -291.5 0.0 0.0 1.0 1.0 LRRK2 -291.5 0.0 1.0 1.0 0.0 ASH2L -300.5 0.0 0.0 0.0 0.0 ANXA2 -300.5 1.0 0.0 0.0 0.0 DUSP3 -304.5 0.0 0.0 1.0 0.0 RAB5C -304.5 0.0 0.0 0.0 0.0 RAB11FIP1 -305.5 1.0 0.0 0.0 0.0 ARNTL -310.5 0.0 1.0 0.0 0.0 TNK2 -311.5 1.0 0.0 1.0 0.0 TERF2IP -315.5 0.0 0.0 1.0 0.0 MAML2 -318.5 0.0 1.0 0.0 0.0 PTGES -321.5 1.0 0.0 0.0 0.0 DUOX2 -324.5 0.0 0.0 0.0 0.0 DUSP4 -325.5 0.0 1.0 0.0 0.0 CBLB -330.5 1.0 0.0 1.0 0.0 ALDH1A1 -334.5 0.0 0.0 0.0 0.0 CDCP1 -335.5 0.0 0.0 1.0 0.0 LAMC2 -340.5 0.0 0.0 0.0 0.0 HCAR2 -348.5 0.0 0.0 0.0 0.0 EGFL7 -352.5 0.0 0.0 0.0 0.0 GPRC5A -353.5 0.0 0.0 0.0 0.0 RHBDL2 -360.5 0.0 0.0 1.0 0.0 STAM2 -368.5 1.0 0.0 1.0 0.0 RABEP1 -369.5 1.0 0.0 0.0 0.0 EPS15 -374.5 1.0 0.0 1.0 0.0 AKTIP -380.5 0.0 0.0 1.0 0.0