+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Diffusion | Diffusion | AUROC |    Zt     |    Zt     |    Zf     | Zf (unif |
|   FROM    |    TO     |       | (degree-  | (uniform) | (degree-  |   orm)   |
|           |           |       | matched)  |           | matched)  |          |
+===========+===========+=======+===========+===========+===========+==========+
| ADNI only | ADSP      | 0.457 | -1.350    | -1.177    | -1.714    | -1.513   |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP only | ADNI      | 0.364 | -2.128    | -2.633    | -1.817    | -1.764   |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADNI only | ADSP only | 0.449 | -1.492    | -1.309    | -1.640    | -1.344   |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP only | ADNI only | 0.350 | -1.971    | -2.389    | -1.970    | -1.815   |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADNI only | Overlappe | 0.916 | 2.235 *   | 1.521 *   | 1.106     | 0.864    |
|           | d         |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP only | Overlappe | 0.746 | -1.234 *  | 1.161 *   | -1.250 *  | -0.811 * |
|           | d         |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Overlappe | Non-overl | 0.519 | 1.661     | 0.653 *   | 6.487 *   | 1.573    |
| d         | apped     |       |           |           |           |          |
|           | genes in  |       |           |           |           |          |
|           | both      |       |           |           |           |          |
|           | groups    |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs
Zf : when randomizing source genes (Diffusion FROM)
Zf : when randomizing recipient genes (Diffusion TO)
Random genes are selected either uniformly or degree matched
* : Distribution of random AUROC is not Gaussian



+------------+---------+--------+------------------+------+
|     **     | #Mapped | #Total | Not mapped genes |      |
+============+=========+========+==================+======+
| ADNI Only  | 27      | 27     |                  | N/A  |
+------------+---------+--------+------------------+------+
| ADSP Only  | 52      | 53     | IQCF6            | N/A  |
+------------+---------+--------+------------------+------+
| Overlapped | 1       | 1      |                  | APOE |
+------------+---------+--------+------------------+------+