+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Diffusion | Diffusion | AUROC |    Zt     |    Zt     |    Zf     | Zf (unif |
|   FROM    |    TO     |       | (degree-  | (uniform) | (degree-  |   orm)   |
|           |           |       | matched)  |           | matched)  |          |
+===========+===========+=======+===========+===========+===========+==========+
| Martinet  | ADSP_iDEA | 0.577 | 1.480     | 3.507     | 2.519     | 2.374    |
| only      | L_pathoge |       |           |           |           |          |
|           | nic       |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP_iDEA | Martinet  | 0.686 | 3.585     | 4.344     | 1.440     | 1.936    |
| L_pathoge |           |       |           |           |           |          |
| nic only  |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Martinet  | ADSP_iDEA | 0.571 | 1.476     | 3.052     | 2.623     | 2.357 *  |
| only      | L_pathoge |       |           |           |           |          |
|           | nic only  |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP_iDEA | Martinet  | 0.674 | 2.285 *   | 4.762     | 1.109     | 1.563    |
| L_pathoge | only      |       |           |           |           |          |
| nic only  |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Martinet  | Overlappe | 0.949 | 2.311     | 2.244     | 1.966     | 2.340    |
| only      | d         |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP_iDEA | Overlappe | 0.939 | 2.666     | 2.307     | 2.488     | 2.798    |
| L_pathoge | d         |       |           |           |           |          |
| nic only  |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Overlappe | Non-overl | 0.567 | 0.738     | 3.067     | 0.383     | 0.902    |
| d         | apped     |       |           |           |           |          |
|           | genes in  |       |           |           |           |          |
|           | both      |       |           |           |           |          |
|           | groups    |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs
Zf : when randomizing source genes (Diffusion FROM)
Zf : when randomizing recipient genes (Diffusion TO)
Random genes are selected either uniformly or degree matched
* : Distribution of random AUROC is not Gaussian



+-----------------------+---------+--------+-----------------------+-----------+
|          **           | #Mapped | #Total |   Not mapped genes    |           |
+=======================+=========+========+=======================+===========+
| Martinet Only         | 45      | 46     | cDNA FLJ60385         | N/A       |
+-----------------------+---------+--------+-----------------------+-----------+
| ADSP_iDEAL_pathogenic | 142     | 146    | MAL2;DCDC1;VSTM5;MGME | N/A       |
| Only                  |         |        | 1                     |           |
+-----------------------+---------+--------+-----------------------+-----------+
| Overlapped            | 2       | 2      |                       | TNR;NOP56 |
+-----------------------+---------+--------+-----------------------+-----------+