+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Diffusion | Diffusion | AUROC |    Zt     |    Zt     |    Zf     | Zf (unif |
|   FROM    |    TO     |       | (degree-  | (uniform) | (degree-  |   orm)   |
|           |           |       | matched)  |           | matched)  |          |
+===========+===========+=======+===========+===========+===========+==========+
| ADSP only | Marttinen | 0.588 | -0.453 *  | 1.685     | -0.622    | -0.624   |
|           | _protein_ |       |           |           |           |          |
|           | randomFor |       |           |           |           |          |
|           | est       |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Marttinen | ADSP      | 0.486 | -0.490    | -0.311    | -0.488    | -0.414   |
| _protein_ |           |       |           |           |           |          |
| randomFor |           |       |           |           |           |          |
| est only  |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP only | Marttinen | 0.593 | -0.255    | 1.515 *   | -0.325    | -0.431   |
|           | _protein_ |       |           |           |           |          |
|           | randomFor |       |           |           |           |          |
|           | est only  |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Marttinen | ADSP only | 0.478 | -0.653    | -0.536    | -0.579    | -0.623   |
| _protein_ |           |       |           |           |           |          |
| randomFor |           |       |           |           |           |          |
| est only  |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP only | Overlappe | 0.432 | -1.660 *  | -0.189 *  | -2.226 *  | -1.964 * |
|           | d         |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Marttinen | Overlappe | 0.951 | 1.609 *   | 1.653 *   | 0.783 *   | 1.411 *  |
| _protein_ | d         |       |           |           |           |          |
| randomFor |           |       |           |           |           |          |
| est only  |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Overlappe | Non-overl | 0.530 | -0.086    | 0.910     | -0.070    | -0.555   |
| d         | apped     |       |           |           |           |          |
|           | genes in  |       |           |           |           |          |
|           | both      |       |           |           |           |          |
|           | groups    |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs
Zf : when randomizing source genes (Diffusion FROM)
Zf : when randomizing recipient genes (Diffusion TO)
Random genes are selected either uniformly or degree matched
* : Distribution of random AUROC is not Gaussian



+--------------------------------+---------+--------+------------------+-------+
|               **               | #Mapped | #Total | Not mapped genes |       |
+================================+=========+========+==================+=======+
| ADSP Only                      | 52      | 53     | IQCF6            | N/A   |
+--------------------------------+---------+--------+------------------+-------+
| Marttinen_protein_randomForest | 28      | 29     | C9orf172         | N/A   |
| Only                           |         |        |                  |       |
+--------------------------------+---------+--------+------------------+-------+
| Overlapped                     | 1       | 1      |                  | NOP56 |
+--------------------------------+---------+--------+------------------+-------+