+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Diffusion | Diffusion | AUROC |    Zt     |    Zt     |    Zf     | Zf (unif |
|   FROM    |    TO     |       | (degree-  | (uniform) | (degree-  |   orm)   |
|           |           |       | matched)  |           | matched)  |          |
+===========+===========+=======+===========+===========+===========+==========+
| ADSP only | Marttinen | 0.686 | 2.913     | 4.162     | 1.503     | 1.851    |
|           | _topProte |       |           |           |           |          |
|           | in        |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Marttinen | ADSP      | 0.577 | 2.010     | 3.105     | 3         | 2.271    |
| _topProte |           |       |           |           |           |          |
| in only   |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP only | Marttinen | 0.674 | 2.575     | 3.712     | 1.223     | 1.721    |
|           | _topProte |       |           |           |           |          |
|           | in only   |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Marttinen | ADSP only | 0.571 | 1.625     | 2.814     | 2.204 *   | 2.497    |
| _topProte |           |       |           |           |           |          |
| in only   |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| ADSP only | Overlappe | 0.939 | 2.701     | 2.037     | 2.191     | 2.507    |
|           | d         |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Marttinen | Overlappe | 0.949 | 2.643     | 2.212     | 1.842     | 2.156 *  |
| _topProte | d         |       |           |           |           |          |
| in only   |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Overlappe | Non-overl | 0.567 | 0.617     | 2.881     | 0.084 *   | 0.621    |
| d         | apped     |       |           |           |           |          |
|           | genes in  |       |           |           |           |          |
|           | both      |       |           |           |           |          |
|           | groups    |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs
Zf : when randomizing source genes (Diffusion FROM)
Zf : when randomizing recipient genes (Diffusion TO)
Random genes are selected either uniformly or degree matched
* : Distribution of random AUROC is not Gaussian



+-----------------------+---------+--------+-----------------------+-----------+
|          **           | #Mapped | #Total |   Not mapped genes    |           |
+=======================+=========+========+=======================+===========+
| ADSP Only             | 142     | 146    | MAL2;VSTM5;MGME1;DCDC | N/A       |
|                       |         |        | 1                     |           |
+-----------------------+---------+--------+-----------------------+-----------+
| Marttinen_topProtein  | 45      | 46     | cDNA FLJ60385         | N/A       |
| Only                  |         |        |                       |           |
+-----------------------+---------+--------+-----------------------+-----------+
| Overlapped            | 2       | 2      |                       | NOP56;TNR |
+-----------------------+---------+--------+-----------------------+-----------+