+-----------+-----------+-------+-----------+-----------+-----------+----------+ | Diffusion | Diffusion | AUROC | Zt | Zt | Zf | Zf (unif | | FROM | TO | | (degree- | (uniform) | (degree- | orm) | | | | | matched) | | matched) | | +===========+===========+=======+===========+===========+===========+==========+ | protein | Marttinen | 0.680 | 1.956 | 3.496 | 1.531 | 1.409 | +-----------+-----------+-------+-----------+-----------+-----------+----------+ | Marttinen | protein | 0.570 | 0.801 * | 2.042 | 1.110 | 0.953 | +-----------+-----------+-------+-----------+-----------+-----------+----------+ Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs Zf : when randomizing source genes (Diffusion FROM) Zf : when randomizing recipient genes (Diffusion TO) Random genes are selected either uniformly or degree matched * : Distribution of random AUROC is not Gaussian +-----------+---------+--------+------------------+-----+ | ** | #Mapped | #Total | Not mapped genes | | +===========+=========+========+==================+=====+ | protein | 67 | 68 | SLC35G6 | N/A | +-----------+---------+--------+------------------+-----+ | Marttinen | 29 | 30 | C9orf172 | N/A | +-----------+---------+--------+------------------+-----+