+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Diffusion | Diffusion | AUROC |    Zt     |    Zt     |    Zf     | Zf (unif |
|   FROM    |    TO     |       | (degree-  | (uniform) | (degree-  |   orm)   |
|           |           |       | matched)  |           | matched)  |          |
+===========+===========+=======+===========+===========+===========+==========+
| topProtei | Marttinen | 0.431 | -0.917    | -0.722    | -1.102    | -1.403   |
| n         |           |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
| Marttinen | topProtei | 0.525 | 0.359 *   | 0.804     | -0.172    | 0.279    |
|           | n         |       |           |           |           |          |
+-----------+-----------+-------+-----------+-----------+-----------+----------+
Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs
Zf : when randomizing source genes (Diffusion FROM)
Zf : when randomizing recipient genes (Diffusion TO)
Random genes are selected either uniformly or degree matched
* : Distribution of random AUROC is not Gaussian



+------------+---------+--------+-----------------------------------+-----+
|     **     | #Mapped | #Total |         Not mapped genes          |     |
+============+=========+========+===================================+=====+
| topProtein | 95      | 100    | FAM153B;ERV3.1;SSPO;LY6G5B;ZNF735 | N/A |
+------------+---------+--------+-----------------------------------+-----+
| Marttinen  | 8       | 8      |                                   | N/A |
+------------+---------+--------+-----------------------------------+-----+