+-----------+-----------+-------+-----------+-----------+-----------+----------+ | Diffusion | Diffusion | AUROC | Zt | Zt | Zf | Zf (unif | | FROM | TO | | (degree- | (uniform) | (degree- | orm) | | | | | matched) | | matched) | | +===========+===========+=======+===========+===========+===========+==========+ | protein | Marttinen | 0.618 | 0.516 | 2.384 | 0.521 | 0.027 | +-----------+-----------+-------+-----------+-----------+-----------+----------+ | Marttinen | protein | 0.509 | -0.380 | 0.293 | -0.760 * | -0.397 | +-----------+-----------+-------+-----------+-----------+-----------+----------+ Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs Zf : when randomizing source genes (Diffusion FROM) Zf : when randomizing recipient genes (Diffusion TO) Random genes are selected either uniformly or degree matched * : Distribution of random AUROC is not Gaussian +-----------+---------+--------+-----------------------------------+-----+ | ** | #Mapped | #Total | Not mapped genes | | +===========+=========+========+===================================+=====+ | protein | 95 | 100 | LY6G5B;ZNF735;ERV3.1;FAM153B;SSPO | N/A | +-----------+---------+--------+-----------------------------------+-----+ | Marttinen | 29 | 30 | C9orf172 | N/A | +-----------+---------+--------+-----------------------------------+-----+