Diffusion FROM,Diffusion TO,AUROC,Zt (degree-matched),Zt (uniform),Zf (degree-matched),Zf (uniform) CovidGS only,Severe,0.607291193792256,1.854 *,5.764,1.596,0.864 Severe only,CovidGS,0.7764058276285764,6.184,8.199,2.032,2.350 CovidGS only,Severe only,0.6004794625782414,1.734,4.668,1.272,0.952 Severe only,CovidGS only,0.7706135886320691,5.934,8.459 *,2.237,2.415 CovidGS only,Overlapped,0.9902405928709357,3.452 *,3.435,2.180,2.119 Severe only,Overlapped,0.9128283146224601,1.792 *,2.332,0.344 *,0.717 * Overlapped,Non-overlapped genes in both groups,0.6042940078923931,0.059,4.958,2.485 *,0.166 Z-scores are computed for the experimental AUROC based on distributions of the random AUROCs Zf : when randomizing source genes (Diffusion FROM) Zf : when randomizing recipient genes (Diffusion TO) Random genes are selected either uniformly or degree matched * : Distribution of random AUROC is not Gaussian **,#Mapped,#Total,Not mapped genes, CovidGS Only,72,76,ABO;MBL3P;HLA-DRB4,N/A Severe Only,171,172,HYAL3,N/A Overlapped,3,3,,DDX58;OAS3;OAS2