Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	6.20e-01	7.56e-01	6.85e-03	1.23e-02
GeneGroup2 Exclusive	GeneGroup1	5.31e-01	1.35e-01	6.97e-05	5.76e-06
GeneGroup1 Exclusive	GeneGroup2 Exclusive	5.52e-01	8.43e-01	3.04e-03	5.25e-03
GeneGroup2 Exclusive	GeneGroup1 Exclusive	5.07e-01	1.46e-01	4.21e-05	3.46e-06
GeneGroup1 Exclusive	Overlap	5.90e-01	9.93e-01	9.92e-02	7.43e-01
GeneGroup2 Exclusive	Overlap	9.92e-02	5.30e-01	9.92e-02	9.92e-02
Overlap	Exclusives	6.83e-01	6.33e-02	1.27e-01	3.44e-07



Evaluating how well GeneGroup1 genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.85	0.35	-0.16	1.38	-2.56
GeneGroup2 Exclusive	GeneGroup1	0.74	-0.99	-4.56	-0.76	-8.67
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.84	0.26	-0.08	1.17	-3.14
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.73	-0.77	-4.18	-0.79	-10.14
GeneGroup1 Exclusive	Overlap	0.97	0.35	-0.52	nan	nan
GeneGroup2 Exclusive	Overlap	1.00	1.00	1.17	2.03	0.86
Overlap	Exclusives	0.71	-0.88	-2.79	-0.82	-9.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.00	-0.26	-0.15	-0.08	-0.92
GeneGroup2 Exclusive	GeneGroup1	0.00	0.61	0.47	1.66	-0.78
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.00	-0.33	-0.26	-0.24	-0.99
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.00	-0.29	-0.25	-0.49	-2.00
GeneGroup1 Exclusive	Overlap	0.00	-0.38	-0.68	nan	nan
GeneGroup2 Exclusive	Overlap	0.03	5.98	1.39	32.81	86.25
Overlap	Exclusives	0.01	1.30	9.21	12.94	3.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1 Exclusive	49	25	ZNF528;CRYGB;SEZ6;OR52J3;ZNF488;RARS;PRAMEF12;PHF21B;OR4C6;ST3GAL5;OR7A5;KRT27;EMID1;RNASE9;PRAMEF6;PRAMEF20;ALPP;WFDC10B;PRAMEF10;PDCD6IP;TRIM51;CCDC83;PRAMEF1;WFDC8
GeneGroup2 Exclusive	11	8	Parkin;GBA;DJ-1
Overlap	1	1