Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	4.84e-01	6.78e-01	6.21e-03	1.97e-02
GeneGroup2 Exclusive	GeneGroup1	5.80e-01	1.29e-01	3.50e-05	6.71e-06
GeneGroup1 Exclusive	GeneGroup2 Exclusive	6.13e-01	7.96e-01	2.45e-03	5.91e-03
GeneGroup2 Exclusive	GeneGroup1 Exclusive	4.98e-01	1.15e-01	2.09e-05	1.58e-06
GeneGroup1 Exclusive	Overlap	5.30e-01	9.95e-01	9.92e-02	5.70e-01
GeneGroup2 Exclusive	Overlap	9.92e-02	4.72e-01	9.92e-02	1.05e-01
Overlap	Exclusives	6.68e-01	5.01e-02	9.67e-02	2.24e-07



Evaluating how well GeneGroup1 genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.85	0.66	-0.26	1.70	-2.66
GeneGroup2 Exclusive	GeneGroup1	0.74	-0.83	-4.85	-0.96	-9.76
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.84	0.12	0.01	1.16	-2.82
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.73	-0.81	-4.36	-1.02	-9.68
GeneGroup1 Exclusive	Overlap	0.97	0.42	-0.40	nan	0.58
GeneGroup2 Exclusive	Overlap	1.00	1.00	1.26	2.14	0.90
Overlap	Exclusives	0.71	-0.92	-3.37	-0.97	-10.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.00	-0.19	-0.20	-0.08	-1.23
GeneGroup2 Exclusive	GeneGroup1	0.00	0.92	0.11	1.95	-0.81
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.00	-0.45	-0.14	-0.22	-0.54
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.00	-0.17	-0.21	-0.44	-2.36
GeneGroup1 Exclusive	Overlap	0.00	-0.30	-0.58	nan	-0.20
GeneGroup2 Exclusive	Overlap	0.03	5.16	1.49	48.80	9.90
Overlap	Exclusives	0.01	1.30	11.81	11.95	13.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1 Exclusive	49	25	OR4C6;ZNF528;TRIM51;KRT27;ST3GAL5;SEZ6;RNASE9;ALPP;PRAMEF1;WFDC10B;CCDC83;OR52J3;CRYGB;PRAMEF12;EMID1;RARS;PRAMEF10;PDCD6IP;PRAMEF20;PHF21B;PRAMEF6;ZNF488;WFDC8;OR7A5
GeneGroup2 Exclusive	11	8	Parkin;DJ-1;GBA
Overlap	1	1