Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	6.62e-01	7.11e-01	5.81e-03	1.99e-02
GeneGroup2 Exclusive	GeneGroup1	5.53e-01	1.28e-01	6.32e-05	4.66e-06
GeneGroup1 Exclusive	GeneGroup2 Exclusive	5.95e-01	7.86e-01	2.78e-03	5.05e-03
GeneGroup2 Exclusive	GeneGroup1 Exclusive	5.70e-01	1.12e-01	4.28e-05	2.24e-06
GeneGroup1 Exclusive	Overlap	5.30e-01	9.93e-01	9.92e-02	6.73e-01
GeneGroup2 Exclusive	Overlap	9.92e-02	4.35e-01	9.92e-02	9.92e-02
Overlap	Exclusives	6.71e-01	5.86e-02	9.81e-02	4.14e-07



Evaluating how well GeneGroup1 genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.85	0.28	-0.36	1.23	-2.35
GeneGroup2 Exclusive	GeneGroup1	0.74	-0.73	-4.46	-0.98	-10.02
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.84	0.21	-0.13	1.28	-2.45
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.73	-0.80	-5.19	-0.79	-10.82
GeneGroup1 Exclusive	Overlap	0.97	0.42	-0.49	nan	0.44
GeneGroup2 Exclusive	Overlap	1.00	0.99	1.28	2.18	0.85
Overlap	Exclusives	0.71	-0.88	-3.74	-1.12	-9.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.00	-0.22	-0.38	-0.08	-0.94
GeneGroup2 Exclusive	GeneGroup1	0.00	2.73	0.13	1.96	-0.90
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.00	-0.20	-0.19	-0.18	-1.36
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.00	-0.42	-0.39	-0.52	-2.56
GeneGroup1 Exclusive	Overlap	0.00	-0.31	-0.67	nan	-0.29
GeneGroup2 Exclusive	Overlap	0.03	5.55	1.56	241.44	64.04
Overlap	Exclusives	0.01	1.33	9.00	48.82	11.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1 Exclusive	49	25	WFDC10B;RNASE9;TRIM51;PHF21B;OR52J3;PRAMEF6;CRYGB;RARS;KRT27;WFDC8;PDCD6IP;PRAMEF12;PRAMEF1;PRAMEF10;ZNF528;SEZ6;EMID1;ALPP;ZNF488;ST3GAL5;OR4C6;OR7A5;CCDC83;PRAMEF20
GeneGroup2 Exclusive	11	8	DJ-1;Parkin;GBA
Overlap	1	1