Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Waveletv11 Exclusive	ViralGS	1.25e-01	3.14e-01	6.85e-08	1.34e-01
ViralGS Exclusive	Waveletv11	3.24e-01	1.35e-01	3.01e-02	1.18e-07
Waveletv11 Exclusive	ViralGS Exclusive	7.33e-02	3.01e-01	9.35e-08	6.43e-02
ViralGS Exclusive	Waveletv11 Exclusive	3.87e-01	1.04e-01	1.36e-02	3.85e-08
Waveletv11 Exclusive	Overlap	3.79e-01	1.00e+00	4.89e-01	2.75e-01
ViralGS Exclusive	Overlap	3.36e-01	9.89e-01	2.01e-01	4.56e-04
Overlap	Exclusives	9.95e-01	8.77e-02	8.39e-08	1.91e-02



Evaluating how well Waveletv11 genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv11 Exclusive	ViralGS	0.93	-1.35	-1.82	-1.74	-1.29
ViralGS Exclusive	Waveletv11	0.86	-0.59	-5.02	0.05	-7.78
Waveletv11 Exclusive	ViralGS Exclusive	0.93	-1.43	-1.73	-1.60	-1.64
ViralGS Exclusive	Waveletv11 Exclusive	0.86	-0.43	-5.60	-0.16	-7.73
Waveletv11 Exclusive	Overlap	0.97	0.71	-0.29	-1.92	1.00
ViralGS Exclusive	Overlap	1.00	3.07	1.19	1.71	1.89
Overlap	Exclusives	0.87	-0.83	-1.53	-0.10	-4.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv11 Exclusive	ViralGS	0.01	-0.94	-1.55	-1.73	-1.01
ViralGS Exclusive	Waveletv11	0.01	0.85	-0.62	-0.14	-1.45
Waveletv11 Exclusive	ViralGS Exclusive	0.01	-1.17	-1.33	-1.72	-1.46
ViralGS Exclusive	Waveletv11 Exclusive	0.01	-0.19	-0.70	-0.58	-2.05
Waveletv11 Exclusive	Overlap	0.00	3.97	-0.32	-0.63	2.11
ViralGS Exclusive	Overlap	0.02	1.66	3.47	0.34	3.96
Overlap	Exclusives	0.04	0.65	5.63	2.75	1.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Waveletv11 Exclusive	149	99	CYP4B1;MAPK13;FOXK2;FN1;H6PD;MYH7B;PASK;ADCY4;TTBK1;UQCRC1;MYO9B;CENPE;ITPKB;POLR1B;PLG;DPYD;LAMB3;PLCE1;PLD2;DDX60L;DHX37;TUBA3E;RRP7A;SGK494;RELN;SPHKAP;NACA2;GNGT2;ASB18;SUCLG2;GFAP;EFCAB13;ITPKC;ASB16;ANXA11;RAD21L1;COQ2;AGL;GOT2;POTEE;THBS1;ANKRD53;AGRN;PMPCB;PENK;ANKEF1;HDHD1;PGR;DDX49;DHODH
ViralGS Exclusive	102	80	IL18BP;ACE2;ZCRB1;CD14;MBL3P;CEACAM1;TMPRSS2;ABO;ITK;IFITM1;CD209;CCR9;SNORA31;POLR3C;FUT2;HLA-DQB1;ANPEP;REN;AGTR2;EIF4E;PPIA;OAS2
Overlap	6	5	TLR1