Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Waveletv11 Exclusive	CovidGS	6.08e-02	3.73e-01	2.94e-04	1.43e-01
CovidGS Exclusive	Waveletv11	2.57e-01	4.55e-02	7.52e-03	7.52e-09
Waveletv11 Exclusive	CovidGS Exclusive	6.89e-02	4.06e-01	4.42e-04	2.63e-01
CovidGS Exclusive	Waveletv11 Exclusive	2.20e-01	3.19e-02	5.42e-03	7.65e-09
Waveletv11 Exclusive	Overlap	6.11e-01	8.47e-01	1.19e-01	6.65e-01
CovidGS Exclusive	Overlap	1.05e-01	1.49e-01	1.05e-01	2.20e-01
Overlap	Exclusives	5.96e-01	9.96e-02	2.40e-01	5.38e-04



Evaluating how well Waveletv11 genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv11 Exclusive	CovidGS	0.93	-2.76	-0.67	-0.92	-0.74
CovidGS Exclusive	Waveletv11	0.86	-1.02	-5.77	-0.66	-8.45
Waveletv11 Exclusive	CovidGS Exclusive	0.93	-2.47	-0.89	-0.95	-0.54
CovidGS Exclusive	Waveletv11 Exclusive	0.86	-1.21	-5.91	-0.75	-8.35
Waveletv11 Exclusive	Overlap	0.94	-0.59	0.05	nan	nan
CovidGS Exclusive	Overlap	1.00	3.43	1.26	nan	nan
Overlap	Exclusives	0.85	-0.24	-3.67	-0.29	-5.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv11 Exclusive	CovidGS	0.01	-1.79	-1.90	-1.24	-0.57
CovidGS Exclusive	Waveletv11	0.01	-1.16	-1.64	-0.74	-1.60
Waveletv11 Exclusive	CovidGS Exclusive	0.01	-1.56	-1.72	-1.29	-0.58
CovidGS Exclusive	Waveletv11 Exclusive	0.01	-1.67	-1.33	-0.85	-1.78
Waveletv11 Exclusive	Overlap	0.00	-0.27	-0.35	nan	nan
CovidGS Exclusive	Overlap	0.00	8.26	3.49	nan	nan
Overlap	Exclusives	0.02	1.25	3.38	0.84	0.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Waveletv11 Exclusive	154	103	GFAP;ITPKC;RELN;ANXA11;MYO9B;RRP7A;UQCRC1;CENPE;DDX49;SUCLG2;EFCAB13;ANKEF1;PASK;PMPCB;PLD2;ANKRD53;THBS1;AGL;COQ2;ADCY4;DPYD;FOXK2;SGK494;MAPK13;PGR;PENK;CYP4B1;ASB16;TLR1;HDHD1;ITPKB;SPHKAP;TTBK1;DHX37;LAMB3;NACA2;POLR1B;POTEE;GNGT2;TUBA3E;AGRN;DDX60L;GOT2;PLCE1;ASB18;H6PD;RAD21L1;FN1;PLG;DHODH;MYH7B
CovidGS Exclusive	77	60	ABO;IFITM1;CD209;ACE2;HLA-DQB1;CEACAM1;MBL3P;AGTR2;TMPRSS2;CCR9;REN;ANPEP;CD14;PPIA;EIF4E;OAS2;ZCRB1
Overlap	1	1