Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Waveletv11 Exclusive	GeneGroup2	5.16e-02	3.94e-01	2.67e-04	2.41e-01
GeneGroup2 Exclusive	Waveletv11	2.30e-01	4.40e-02	6.47e-03	4.66e-09
Waveletv11 Exclusive	GeneGroup2 Exclusive	7.10e-02	4.75e-01	6.49e-04	2.20e-01
GeneGroup2 Exclusive	Waveletv11 Exclusive	2.62e-01	5.08e-02	1.18e-02	8.49e-09
Waveletv11 Exclusive	Overlap	8.11e-01	8.64e-01	1.51e-01	6.30e-01
GeneGroup2 Exclusive	Overlap	1.12e-01	1.85e-01	1.12e-01	1.72e-01
Overlap	Exclusives	6.63e-01	1.12e-01	9.34e-02	2.96e-04



Evaluating how well Waveletv11 genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv11 Exclusive	GeneGroup2	0.93	-2.72	-0.57	-0.91	-0.37
GeneGroup2 Exclusive	Waveletv11	0.86	-1.21	-5.38	-0.94	-9.31
Waveletv11 Exclusive	GeneGroup2 Exclusive	0.93	-2.67	-0.73	-0.97	-0.67
GeneGroup2 Exclusive	Waveletv11 Exclusive	0.86	-1.09	-6.38	-0.67	-8.08
Waveletv11 Exclusive	Overlap	0.94	-0.40	0.15	nan	nan
GeneGroup2 Exclusive	Overlap	1.00	2.70	1.21	nan	nan
Overlap	Exclusives	0.85	-0.47	-3.40	-0.20	-5.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv11 Exclusive	GeneGroup2	0.01	-1.62	-1.60	-1.34	-0.49
GeneGroup2 Exclusive	Waveletv11	0.01	-1.42	-1.31	-0.73	-2.30
Waveletv11 Exclusive	GeneGroup2 Exclusive	0.01	-1.67	-1.63	-1.47	-0.41
GeneGroup2 Exclusive	Waveletv11 Exclusive	0.01	-1.48	-1.74	-0.75	-2.08
Waveletv11 Exclusive	Overlap	0.00	-0.26	-0.41	nan	nan
GeneGroup2 Exclusive	Overlap	0.00	4.72	2.77	nan	nan
Overlap	Exclusives	0.02	1.20	2.79	0.74	0.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Waveletv11 Exclusive	154	103	GNGT2;TUBA3E;DDX49;POTEE;GFAP;MYO9B;PASK;DPYD;TTBK1;ASB18;PLCE1;DDX60L;ANKRD53;PENK;LAMB3;RRP7A;ANKEF1;H6PD;AGL;PLG;AGRN;PMPCB;COQ2;HDHD1;SUCLG2;FN1;CYP4B1;ITPKC;RAD21L1;TLR1;DHX37;PGR;ASB16;THBS1;SPHKAP;MAPK13;POLR1B;UQCRC1;MYH7B;NACA2;ANXA11;FOXK2;ITPKB;PLD2;EFCAB13;CENPE;RELN;GOT2;ADCY4;DHODH;SGK494
GeneGroup2 Exclusive	77	60	TMPRSS2;PPIA;EIF4E;ACE2;ANPEP;MBL3P;CEACAM1;CCR9;ABO;HLA-DQB1;ZCRB1;REN;AGTR2;OAS2;CD14;IFITM1;CD209
Overlap	1	1