Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAfamilial_GS	7.48e-01	8.91e-01	1.79e-03	2.65e-02
BRCAfamilial_GS Exclusive	hg38_Wavelet_genes	8.69e-01	9.76e-01	7.94e-03	1.36e-03
hg38_Wavelet_genes Exclusive	BRCAfamilial_GS Exclusive	7.00e-01	9.87e-01	1.77e-03	1.72e-01
BRCAfamilial_GS Exclusive	hg38_Wavelet_genes Exclusive	8.55e-01	8.76e-01	5.24e-03	2.03e-04
hg38_Wavelet_genes Exclusive	Overlap	5.61e-01	4.46e-01	2.72e-01	5.29e-02
BRCAfamilial_GS Exclusive	Overlap	2.21e-02	8.26e-02	4.94e-05	1.69e-05
Overlap	Exclusives	7.74e-01	5.44e-01	4.58e-07	1.17e-02



Evaluating how well hg38_Wavelet_genes genes are linked to BRCAfamilial_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAfamilial_GS	0.97	-0.29	1.61	-0.79	2.41
BRCAfamilial_GS Exclusive	hg38_Wavelet_genes	0.91	1.76	-0.44	2.30	-4.47
hg38_Wavelet_genes Exclusive	BRCAfamilial_GS Exclusive	0.97	-0.89	0.89	-1.24	1.84
BRCAfamilial_GS Exclusive	hg38_Wavelet_genes Exclusive	0.90	1.65	-0.88	2.69	-5.02
hg38_Wavelet_genes Exclusive	Overlap	0.98	0.99	1.48	0.55	1.55
BRCAfamilial_GS Exclusive	Overlap	1.00	1.32	2.62	1.72	2.06
Overlap	Exclusives	0.92	0.84	-0.36	1.88	-3.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAfamilial_GS	0.01	-0.45	0.33	-0.83	1.78
BRCAfamilial_GS Exclusive	hg38_Wavelet_genes	0.03	0.90	3.98	5.00	1.70
hg38_Wavelet_genes Exclusive	BRCAfamilial_GS Exclusive	0.01	-0.61	0.26	-0.66	1.76
BRCAfamilial_GS Exclusive	hg38_Wavelet_genes Exclusive	0.01	0.37	0.45	0.72	-1.66
hg38_Wavelet_genes Exclusive	Overlap	0.00	-0.31	0.04	-0.23	0.67
BRCAfamilial_GS Exclusive	Overlap	0.16	0.57	12.92	6.08	61.23
Overlap	Exclusives	0.07	8.57	7.00	14.06	9.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_Wavelet_genes Exclusive	156	112	PMPCB;DBI;IRAK2;WDR31;HJURP;YARS2;ZSCAN5A;ABL1;ZNF559;MNS1;MPP3;MYL5;MAPK3;ITGA6;OAS2;MYO6;ZNF544;RPL3L;RPS6KA2;ZNF92;GAPDH;MYO9B;POLI;ZNF44;RNASEL;ENO3;NRIP1;RNASE9;MRPL13;NPHP3;POLR1B;FN1;TLR1;ZNF254;RRM2B;GALR2;RNASE12;TPBG;PYGB;MAPK6;TYW1;SUCLG2;ADCY7;MAPK12
BRCAfamilial_GS Exclusive	23	22	NF1
Overlap	8	6	ESR1;MUTYH