Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Waveletv10 Exclusive	ViralGS	2.09e-01	4.27e-01	3.90e-05	3.62e-01
ViralGS Exclusive	Waveletv10	3.01e-01	5.88e-01	5.96e-02	8.04e-03
Waveletv10 Exclusive	ViralGS Exclusive	1.59e-01	3.91e-01	5.29e-06	1.34e-01
ViralGS Exclusive	Waveletv10 Exclusive	2.20e-01	5.08e-01	2.64e-02	1.04e-03
Waveletv10 Exclusive	Overlap	7.98e-01	9.73e-01	7.15e-02	6.51e-01
ViralGS Exclusive	Overlap	9.21e-02	5.23e-01	3.52e-02	1.19e-04
Overlap	Exclusives	7.67e-01	1.06e-02	2.25e-05	1.63e-02



Evaluating how well Waveletv10 genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv10 Exclusive	ViralGS	0.93	-0.94	-1.01	-1.24	-0.70
ViralGS Exclusive	Waveletv10	0.90	-0.94	-2.20	-0.58	-3.79
Waveletv10 Exclusive	ViralGS Exclusive	0.93	-0.90	-0.97	-1.36	-1.02
ViralGS Exclusive	Waveletv10 Exclusive	0.89	-1.15	-2.97	-1.22	-4.13
Waveletv10 Exclusive	Overlap	0.95	-1.05	-1.07	-1.35	0.26
ViralGS Exclusive	Overlap	1.00	2.30	2.26	2.13	2.19
Overlap	Exclusives	0.90	0.06	0.22	-0.17	-1.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv10 Exclusive	ViralGS	0.01	-0.83	-1.44	-1.74	-1.01
ViralGS Exclusive	Waveletv10	0.02	0.64	0.49	0.15	-0.98
Waveletv10 Exclusive	ViralGS Exclusive	0.01	-0.99	-1.63	-1.54	-1.21
ViralGS Exclusive	Waveletv10 Exclusive	0.01	-0.84	-0.35	-1.21	-1.67
Waveletv10 Exclusive	Overlap	0.00	0.13	-0.84	-0.92	-0.04
ViralGS Exclusive	Overlap	0.03	4.90	18.65	1.23	3.99
Overlap	Exclusives	0.05	6.13	7.52	4.09	2.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Waveletv10 Exclusive	149	105	GNGT2;ADCY4;GABPB2;FOXK2;PABPC1;SUCLG2;EPHA2;H6PD;DNAH8;NT5C;LAMB3;GOT2;POLR1B;ASB16;MAPK13;PASK;ZNF611;GFAP;MYO9B;DHODH;UROD;ME1;CYP4B1;PGR;ZNF700;FN1;SEMA4D;RELN;THBS1;PMPCB;PLG;PDGFB;SRC;UQCRC1;PRKCH;POLN;ANKRD53;ADCY7;LYZ;AKR1C1;CENPE;DPYD;PENK;ACTR1B
ViralGS Exclusive	101	79	CD209;ANPEP;ITK;ACE2;MBL3P;TMPRSS2;POLR3C;EIF4E;REN;AGTR2;FUT2;CEACAM1;CD14;OAS2;PPIA;HLA-DQB1;ZCRB1;ABO;CCR9;IL18BP;IFITM1;SNORA31
Overlap	7	6	TLR1