Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Waveletv10 Exclusive	ViralGS	3.57e-03	1.04e-02	2.21e-20	2.43e-11
ViralGS Exclusive	Waveletv10	2.31e-05	6.98e-06	4.11e-13	4.60e-27
Waveletv10 Exclusive	ViralGS Exclusive	1.35e-02	4.46e-02	2.17e-19	7.93e-11
ViralGS Exclusive	Waveletv10 Exclusive	6.70e-04	3.71e-05	6.21e-11	5.38e-25
Waveletv10 Exclusive	Overlap	2.81e-01	1.16e-01	2.42e-05	1.66e-04
ViralGS Exclusive	Overlap	3.30e-07	4.12e-07	3.30e-07	6.12e-07
Overlap	Exclusives	2.89e-18	8.43e-18	5.14e-67	3.38e-55



Evaluating how well Waveletv10 genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv10 Exclusive	ViralGS	0.74	2.60	3.71	2.29	7.79
ViralGS Exclusive	Waveletv10	0.79	0.58	7.09	3.22	11.67
Waveletv10 Exclusive	ViralGS Exclusive	0.73	2.18	3.95	2.42	7.40
ViralGS Exclusive	Waveletv10 Exclusive	0.78	0.44	5.08	3.47	11.55
Waveletv10 Exclusive	Overlap	0.93	1.56	1.83	1.95	3.69
ViralGS Exclusive	Overlap	0.99	2.84	5.55	3.36	4.32
Overlap	Exclusives	0.83	5.62	11.46	3.04	17.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Waveletv10 Exclusive	ViralGS	0.02	5.35	3.78	5.26	22.53
ViralGS Exclusive	Waveletv10	0.03	0.21	12.01	5.12	11.03
Waveletv10 Exclusive	ViralGS Exclusive	0.02	4.27	3.48	4.67	15.53
ViralGS Exclusive	Waveletv10 Exclusive	0.02	-0.76	5.95	4.76	16.86
Waveletv10 Exclusive	Overlap	0.01	5.45	3.03	8.82	10.73
ViralGS Exclusive	Overlap	0.03	25.62	132.68	70.19	92.59
Overlap	Exclusives	0.08	16.74	46.05	13.83	76.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Waveletv10 Exclusive	149	149	
ViralGS Exclusive	101	97	SNORA31;ABO;HLA-DRB4;MBL3P
Overlap	7	7