Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hallmark	gwas	4.91e-19	5.31e-18	1.89e-19	3.90e-18
gwas	hallmark	2.10e-05	2.10e-05	2.10e-05	2.19e-05



Evaluating how well hallmark genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hallmark	gwas	0.99	16.23	9.98	4.08	8.55
gwas	hallmark	1.00	3.18	6.39	3.16	3.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hallmark	gwas	0.12	739.15	248.50	183.16	305.95
gwas	hallmark	0.07	150.03	294.03	158.02	158.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hallmark	5	5	
gwas	23	23