Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML Exclusive	ViralGS	9.50e-02	2.98e-01	2.13e-01	2.68e-03
ViralGS Exclusive	EAML	1.19e-01	9.16e-01	2.11e-01	7.72e-01
EAML Exclusive	ViralGS Exclusive	6.23e-02	2.58e-01	2.24e-01	2.50e-03
ViralGS Exclusive	EAML Exclusive	1.00e-01	7.45e-01	2.18e-01	8.85e-01
EAML Exclusive	Overlap	2.78e-01	4.35e-01	5.70e-01	3.83e-01
ViralGS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.18e-01
Overlap	Exclusives	5.15e-13	1.02e-08	2.66e-34	9.31e-18



Evaluating how well EAML genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	ViralGS	0.61	-0.81	-1.26	-0.59	3.51
ViralGS Exclusive	EAML	0.51	0.55	-0.67	0.62	0.41
EAML Exclusive	ViralGS Exclusive	0.61	-0.79	-1.41	-0.50	4.03
ViralGS Exclusive	EAML Exclusive	0.50	0.12	-0.92	0.51	0.28
EAML Exclusive	Overlap	0.61	-0.88	-0.11	-0.40	0.66
ViralGS Exclusive	Overlap	0.97	2.30	2.54	2.05	1.81
Overlap	Exclusives	0.66	4.06	6.90	1.79	6.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	ViralGS	0.01	-0.37	0.24	-0.23	3.16
ViralGS Exclusive	EAML	0.01	0.00	-0.34	-0.08	-0.19
EAML Exclusive	ViralGS Exclusive	0.01	-0.33	0.25	-0.05	4.56
ViralGS Exclusive	EAML Exclusive	0.01	-0.19	-0.41	-0.08	-0.29
EAML Exclusive	Overlap	0.00	-0.55	-0.44	-0.33	-0.19
ViralGS Exclusive	Overlap	0.00	7.41	16.15	7.98	0.05
Overlap	Exclusives	0.02	6.68	10.70	1.44	10.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML Exclusive	111	108	PRR5-ARHGAP8;FAM217A;GIMD1
ViralGS Exclusive	107	103	ABO;MBL3P;HLA-DRB4;SNORA31
Overlap	1	1