Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML Exclusive	CovidGS	1.79e-01	9.07e-02	2.23e-01	1.72e-03
CovidGS Exclusive	EAML	2.79e-01	7.11e-01	3.15e-02	9.41e-01
EAML Exclusive	CovidGS Exclusive	2.81e-01	8.44e-02	1.32e-01	1.25e-03
CovidGS Exclusive	EAML Exclusive	2.83e-01	7.24e-01	3.60e-02	9.69e-01
EAML Exclusive	Overlap	2.06e-01	2.65e-01	6.11e-01	5.90e-01
CovidGS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.18e-01
Overlap	Exclusives	4.45e-10	3.21e-05	1.92e-30	3.47e-11



Evaluating how well EAML genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	CovidGS	0.65	-0.74	-0.09	-0.32	4.08
CovidGS Exclusive	EAML	0.51	0.95	-0.42	0.75	0.44
EAML Exclusive	CovidGS Exclusive	0.65	-0.49	-0.08	-0.19	4.68
CovidGS Exclusive	EAML Exclusive	0.51	1.02	-0.35	0.66	0.35
EAML Exclusive	Overlap	0.61	-1.06	-0.46	-0.46	0.35
CovidGS Exclusive	Overlap	0.95	1.90	2.40	1.81	1.66
Overlap	Exclusives	0.64	4.25	4.91	2.00	6.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	CovidGS	0.01	-0.27	2.17	0.12	3.06
CovidGS Exclusive	EAML	0.01	0.65	-0.31	-0.01	0.01
EAML Exclusive	CovidGS Exclusive	0.01	0.08	2.58	0.35	4.36
CovidGS Exclusive	EAML Exclusive	0.01	1.01	-0.32	-0.00	0.01
EAML Exclusive	Overlap	0.00	-0.74	-0.82	-0.50	-0.28
CovidGS Exclusive	Overlap	0.00	1.87	10.58	1.77	1.16
Overlap	Exclusives	0.02	5.20	6.77	1.46	7.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML Exclusive	111	108	GIMD1;FAM217A;PRR5-ARHGAP8
CovidGS Exclusive	77	74	HLA-DRB4;MBL3P;ABO
Overlap	1	1