Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma Exclusive	gwas	8.14e-01	6.86e-01	8.59e-01	1.13e-01
gwas Exclusive	magma	1.80e-02	2.10e-01	1.65e-01	6.61e-01
magma Exclusive	gwas Exclusive	6.27e-01	4.70e-01	6.53e-01	1.10e-01
gwas Exclusive	magma Exclusive	5.40e-03	3.19e-01	1.63e-01	7.18e-01
magma Exclusive	Overlap	6.48e-01	7.44e-01	8.50e-01	8.50e-01
gwas Exclusive	Overlap	1.53e-03	1.53e-03	1.45e-03	1.68e-03
Overlap	Exclusives	6.97e-02	3.69e-02	2.11e-12	3.30e-02



Evaluating how well magma genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma Exclusive	gwas	0.60	0.50	0.53	0.23	1.75
gwas Exclusive	magma	0.50	-1.09	-1.12	-0.82	-0.32
magma Exclusive	gwas Exclusive	0.61	0.72	1.06	0.57	1.73
gwas Exclusive	magma Exclusive	0.49	-1.53	-1.43	-1.16	-0.46
magma Exclusive	Overlap	0.55	-0.92	-1.02	-0.89	0.29
gwas Exclusive	Overlap	0.99	2.78	3.28	3.33	2.58
Overlap	Exclusives	0.54	2.65	1.94	1.67	2.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma Exclusive	gwas	0.00	-0.07	-0.10	-0.24	0.22
gwas Exclusive	magma	0.01	1.09	1.44	1.00	0.71
magma Exclusive	gwas Exclusive	0.00	0.02	0.02	-0.19	0.00
gwas Exclusive	magma Exclusive	0.01	-0.41	0.23	-0.34	0.12
magma Exclusive	Overlap	0.00	0.43	1.01	0.26	0.61
gwas Exclusive	Overlap	0.03	29.31	123.01	65.61	0.72
Overlap	Exclusives	0.02	5.13	7.24	3.04	5.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma Exclusive	231	217	MICA;IGH;SAXO2;SGF29;ADA2;DRC3;ADGRL1;CFAP74;CCDC168;C17orf107;RARS1;PRR27;PSORS1C1;C2CD5
gwas Exclusive	22	21	HLA -DRB1
Overlap	3	3