Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Finnish	Collection_GS	3.33e-01	3.76e-01	2.16e-04	1.99e-05
Collection_GS	Finnish	4.59e-01	8.85e-01	8.59e-01	9.85e-01



Evaluating how well Finnish genes are linked to Collection_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Finnish	Collection_GS	0.67	0.33	1.70	0.35	4.34
Collection_GS	Finnish	0.52	-0.34	-0.71	-0.80	0.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Finnish	Collection_GS	0.00	-0.01	1.63	0.60	2.40
Collection_GS	Finnish	0.00	0.07	0.13	0.21	0.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Finnish	13	13	
Collection_GS	52	50	CENTD2;TMEM195