Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Hispanic	Collection_GS	7.16e-01	4.96e-02	5.83e-02	1.59e-02
Collection_GS	Hispanic	1.81e-01	8.99e-01	1.19e-01	9.61e-01



Evaluating how well Hispanic genes are linked to Collection_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Hispanic	Collection_GS	0.59	-0.07	-1.32	-0.48	2.23
Collection_GS	Hispanic	0.49	0.45	0.41	0.55	-0.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Hispanic	Collection_GS	0.00	-0.28	-1.65	-0.68	0.74
Collection_GS	Hispanic	0.01	-0.29	-0.24	-0.36	-0.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Hispanic	138	134	C19orf55;ZNF259;SMCR7;SYT15
Collection_GS	52	50	CENTD2;TMEM195