Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SouthAsian Exclusive	Collection_GS	2.60e-01	1.44e-01	7.07e-01	1.20e-03
Collection_GS Exclusive	SouthAsian	6.13e-01	1.30e-01	1.69e-02	4.47e-01
SouthAsian Exclusive	Collection_GS Exclusive	2.22e-01	1.03e-01	7.86e-01	1.11e-03
Collection_GS Exclusive	SouthAsian Exclusive	6.26e-01	4.77e-02	9.25e-03	3.17e-01
SouthAsian Exclusive	Overlap	4.35e-01	3.06e-01	4.00e-01	4.00e-01
Collection_GS Exclusive	Overlap	5.30e-01	4.53e-01	6.73e-01	8.11e-01
Overlap	Exclusives	7.77e-01	4.65e-01	2.94e-01	4.86e-01



Evaluating how well SouthAsian genes are linked to Collection_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SouthAsian Exclusive	Collection_GS	0.65	0.68	2.26	0.82	3.41
Collection_GS Exclusive	SouthAsian	0.52	3.32	1.86	1.63	0.57
SouthAsian Exclusive	Collection_GS Exclusive	0.66	1.04	2.22	0.74	3.93
Collection_GS Exclusive	SouthAsian Exclusive	0.52	2.89	2.38	2.09	0.69
SouthAsian Exclusive	Overlap	0.24	-0.77	-0.94	-0.86	-0.87
Collection_GS Exclusive	Overlap	0.47	-0.15	0.21	-0.03	-0.08
Overlap	Exclusives	0.53	-0.60	-0.45	-0.49	1.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SouthAsian Exclusive	Collection_GS	0.00	0.59	2.74	0.78	1.83
Collection_GS Exclusive	SouthAsian	0.01	4.26	0.93	0.16	0.03
SouthAsian Exclusive	Collection_GS Exclusive	0.00	1.02	2.67	0.79	0.50
Collection_GS Exclusive	SouthAsian Exclusive	0.01	2.82	1.62	0.37	0.10
SouthAsian Exclusive	Overlap	0.00	-0.24	-0.48	-0.27	-0.31
Collection_GS Exclusive	Overlap	0.00	-0.25	-0.18	-0.13	-0.23
Overlap	Exclusives	0.01	-0.39	-0.42	-0.36	0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SouthAsian Exclusive	90	89	BCMO1
Collection_GS Exclusive	51	49	CENTD2;TMEM195
Overlap	1	1