Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_EPI Exclusive	CovidGS	3.95e-01	2.50e-01	1.32e-01	4.07e-07
CovidGS Exclusive	EAML_EPI	2.81e-01	6.03e-01	6.25e-03	7.47e-02
EAML_EPI Exclusive	CovidGS Exclusive	2.62e-01	1.87e-01	1.91e-01	2.60e-07
CovidGS Exclusive	EAML_EPI Exclusive	4.14e-01	8.60e-01	6.46e-03	1.54e-01
EAML_EPI Exclusive	Overlap	2.28e-01	2.92e-01	2.28e-01	2.28e-01
CovidGS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.41e-01
Overlap	Exclusives	8.89e-11	3.85e-08	2.39e-28	1.59e-18



Evaluating how well EAML_EPI genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EPI Exclusive	CovidGS	0.69	0.40	1.46	0.57	5.49
CovidGS Exclusive	EAML_EPI	0.57	0.96	0.90	1.33	1.83
EAML_EPI Exclusive	CovidGS Exclusive	0.69	0.42	1.17	0.47	5.37
CovidGS Exclusive	EAML_EPI Exclusive	0.56	0.62	0.30	1.44	1.32
EAML_EPI Exclusive	Overlap	0.87	1.20	1.31	1.18	1.40
CovidGS Exclusive	Overlap	0.95	2.03	2.27	1.91	1.60
Overlap	Exclusives	0.74	3.29	6.28	2.73	9.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EPI Exclusive	CovidGS	0.01	0.45	2.61	1.12	1.63
CovidGS Exclusive	EAML_EPI	0.00	0.98	0.09	1.63	1.84
EAML_EPI Exclusive	CovidGS Exclusive	0.01	0.77	2.77	0.82	2.34
CovidGS Exclusive	EAML_EPI Exclusive	0.00	0.17	0.08	1.34	0.63
EAML_EPI Exclusive	Overlap	0.00	0.35	1.14	0.75	0.22
CovidGS Exclusive	Overlap	0.00	2.56	10.05	4.79	0.21
Overlap	Exclusives	0.02	4.64	9.40	3.03	13.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_EPI Exclusive	45	44	GIMD1
CovidGS Exclusive	77	74	HLA-DRB4;ABO;MBL3P
Overlap	1	1