Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Reactome_Wavelet	CovidGS	8.78e-13	1.02e-13	1.06e-19	3.65e-20
CovidGS	Reactome_Wavelet	3.47e-03	1.14e-02	1.87e-03	6.21e-04



Evaluating how well Reactome_Wavelet genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome_Wavelet	CovidGS	0.84	3.87	8.30	2.53	8.83
CovidGS	Reactome_Wavelet	0.81	2.56	3.30	2.08	5.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome_Wavelet	CovidGS	0.03	14.93	50.91	12.50	37.63
CovidGS	Reactome_Wavelet	0.01	5.94	17.10	8.16	14.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Reactome_Wavelet	16	16	
CovidGS	78	75	ABO;HLA-DRB4;MBL3P