Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Reactome	JLC	2.44e-04	3.25e-06	5.01e-07	5.79e-07
JLC	Reactome	4.34e-02	2.91e-01	4.35e-03	5.86e-06



Evaluating how well Reactome genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome	JLC	0.89	1.96	4.70	2.06	4.44
JLC	Reactome	0.62	0.93	2.31	0.38	6.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome	JLC	0.00	1.02	1.45	0.90	4.31
JLC	Reactome	0.02	0.66	2.27	0.56	6.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Reactome	202	200	COLGALT1;HYAL3
JLC	13	10	NEMO;UNC93B;TRIF