Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet	JLC	5.14e-03	6.17e-03	8.02e-06	9.37e-04
JLC	Wavelet	3.13e-02	1.04e-05	7.19e-07	1.76e-34



Evaluating how well Wavelet genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet	JLC	0.86	4.35	3.38	2.00	4.15
JLC	Wavelet	0.80	2.32	4.42	2.26	13.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet	JLC	0.01	21.22	20.76	7.61	14.21
JLC	Wavelet	0.03	5.95	9.16	5.44	25.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet	156	156	
JLC	13	10	NEMO;UNC93B;TRIF