Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	JLC	8.31e-01	9.51e-01	8.36e-01	4.68e-01
JLC	EPI	3.86e-02	8.76e-01	2.06e-02	9.28e-01



Evaluating how well EPI genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JLC	0.59	-0.39	-0.21	-0.49	0.76
JLC	EPI	0.50	1.37	0.50	0.87	0.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JLC	0.00	-0.42	-0.49	-0.50	-0.14
JLC	EPI	0.01	0.21	0.22	-0.07	-0.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	115	112	EBLN1;CCDC11;GIMD1
JLC	13	10	TRIF;UNC93B;NEMO