Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	JLC	7.39e-01	8.02e-01	7.17e-01	3.39e-01
JLC	EAML	5.92e-03	4.08e-01	2.99e-02	6.16e-01



Evaluating how well EAML genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JLC	0.55	-0.47	-0.89	-0.49	0.60
JLC	EAML	0.49	0.11	-1.05	0.14	-0.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JLC	0.00	-0.36	-0.69	-0.47	-0.12
JLC	EAML	0.01	-0.19	-0.66	-0.39	-0.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	112	109	FAM217A;GIMD1;PRR5-ARHGAP8
JLC	13	10	UNC93B;TRIF;NEMO