Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Overlap	JLC	1.76e-02	4.28e-03	3.55e-03	1.52e-03
JLC	Overlap	1.25e-02	2.86e-01	3.72e-02	4.20e-03



Evaluating how well Overlap genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap	JLC	0.81	1.92	3.08	1.43	3.76
JLC	Overlap	0.62	0.75	0.76	1.13	3.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap	JLC	0.00	0.74	0.62	0.90	1.89
JLC	Overlap	0.01	1.52	2.18	0.76	4.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Overlap	73	72	GIMD1
JLC	13	10	TRIF;NEMO;UNC93B