Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-MI	GWASCatalog	2.24e-01	4.37e-01	1.09e-01	1.02e-01
GWASCatalog	UKB-MI	2.79e-02	2.57e-02	8.84e-02	1.68e-02



Evaluating how well UKB-MI genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI	GWASCatalog	0.58	-1.34	-1.31	-1.29	1.95
GWASCatalog	UKB-MI	0.46	-0.64	-2.74	-1.10	-1.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI	GWASCatalog	0.00	-1.36	-1.16	-0.66	0.11
GWASCatalog	UKB-MI	0.01	-0.40	-1.87	-0.83	-1.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-MI	179	176	CENPC1;RNASE4;ARIH2OS
GWASCatalog	70	69	ODZ3