Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-MI Exclusive	ATVB	2.55e-01	4.29e-01	1.52e-01	1.35e-01
ATVB Exclusive	UKB-MI	6.22e-01	3.12e-01	1.78e-01	1.88e-01
UKB-MI Exclusive	ATVB Exclusive	2.06e-01	4.47e-01	1.51e-01	2.42e-01
ATVB Exclusive	UKB-MI Exclusive	7.18e-01	3.62e-01	9.02e-02	1.57e-01
UKB-MI Exclusive	Overlap	1.33e-01	3.35e-01	1.41e-01	1.05e-01
ATVB Exclusive	Overlap	3.06e-01	6.31e-01	5.30e-01	3.35e-01
Overlap	Exclusives	1.26e-01	8.93e-01	1.76e-45	6.32e-01



Evaluating how well UKB-MI genes are linked to ATVB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI Exclusive	ATVB	0.47	-0.17	-0.31	-0.38	-1.14
ATVB Exclusive	UKB-MI	0.48	0.01	-0.67	0.12	-0.91
UKB-MI Exclusive	ATVB Exclusive	0.48	-0.36	-0.39	-0.25	-0.86
ATVB Exclusive	UKB-MI Exclusive	0.48	0.06	-0.62	-0.25	-1.09
UKB-MI Exclusive	Overlap	0.02	-0.63	-0.69	-0.60	-1.61
ATVB Exclusive	Overlap	0.26	0.18	0.02	0.27	-0.92
Overlap	Exclusives	0.49	-0.38	-0.55	-0.23	-0.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI Exclusive	ATVB	0.01	-0.14	0.32	-0.29	-0.27
ATVB Exclusive	UKB-MI	0.01	-0.32	-0.85	-0.23	-0.86
UKB-MI Exclusive	ATVB Exclusive	0.01	-0.14	0.27	-0.18	-0.32
ATVB Exclusive	UKB-MI Exclusive	0.01	-0.30	-0.67	-0.46	-1.26
UKB-MI Exclusive	Overlap	0.00	-0.24	-0.55	-0.26	-0.54
ATVB Exclusive	Overlap	0.00	-0.18	-0.18	-0.17	-0.29
Overlap	Exclusives	0.01	-0.57	-0.45	-0.42	-0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-MI Exclusive	178	175	ARIH2OS;RNASE4;CENPC1
ATVB Exclusive	116	112	CCDC41;EFCAB4A;ALS2CR8;IFLTD1
Overlap	1	1