Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-MI Exclusive	ATVB	1.28e-01	3.06e-01	4.52e-02	4.75e-01
ATVB Exclusive	UKB-MI	3.33e-01	4.10e-01	5.45e-01	1.54e-01
UKB-MI Exclusive	ATVB Exclusive	1.00e-01	2.35e-01	8.47e-02	3.93e-01
ATVB Exclusive	UKB-MI Exclusive	4.91e-01	2.88e-01	4.86e-01	1.57e-01
UKB-MI Exclusive	Overlap	6.31e-01	4.17e-01	3.06e-01	6.93e-01
ATVB Exclusive	Overlap	1.18e-01	9.92e-02	1.41e-01	1.85e-01
Overlap	Exclusives	3.02e-04	4.11e-01	2.68e-18	8.67e-01



Evaluating how well UKB-MI genes are linked to ATVB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI Exclusive	ATVB	0.48	-0.81	-1.10	-1.14	-0.63
ATVB Exclusive	UKB-MI	0.47	-1.18	-1.37	-0.26	-1.49
UKB-MI Exclusive	ATVB Exclusive	0.48	-0.90	-1.39	-0.71	-0.88
ATVB Exclusive	UKB-MI Exclusive	0.47	-0.86	-1.40	-0.60	-1.47
UKB-MI Exclusive	Overlap	0.47	-0.18	-0.66	-0.63	-0.09
ATVB Exclusive	Overlap	0.93	1.78	1.63	1.88	1.36
Overlap	Exclusives	0.50	0.75	1.09	0.60	0.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI Exclusive	ATVB	0.01	16.92	19.74	18.45	15.24
ATVB Exclusive	UKB-MI	0.01	-0.23	-0.32	0.41	-0.77
UKB-MI Exclusive	ATVB Exclusive	0.02	17.19	18.08	12.53	12.16
ATVB Exclusive	UKB-MI Exclusive	0.01	-0.06	-0.43	-0.09	-0.64
UKB-MI Exclusive	Overlap	0.00	-0.36	-0.64	-0.37	-0.33
ATVB Exclusive	Overlap	0.00	2.28	5.96	1.64	0.27
Overlap	Exclusives	0.02	0.85	1.89	0.47	0.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-MI Exclusive	178	175	ARIH2OS;CENPC1;RNASE4
ATVB Exclusive	116	111	SELRC1;ADC;ZNF23;LOC729020;GPER
Overlap	1	1