Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-MIunder65 Exclusive	ATVB	3.91e-01	6.00e-01	3.43e-01	8.60e-01
ATVB Exclusive	UKB-MIunder65	1.01e-01	2.09e-01	2.36e-01	2.41e-01
UKB-MIunder65 Exclusive	ATVB Exclusive	1.48e-01	2.84e-01	3.02e-01	5.71e-01
ATVB Exclusive	UKB-MIunder65 Exclusive	2.58e-01	2.11e-01	2.06e-01	2.19e-01
UKB-MIunder65 Exclusive	Overlap	5.69e-01	3.80e-01	3.95e-01	4.74e-01
ATVB Exclusive	Overlap	6.41e-01	6.23e-01	6.60e-01	5.16e-01
Overlap	Exclusives	8.90e-01	8.10e-01	3.54e-01	7.99e-01



Evaluating how well UKB-MIunder65 genes are linked to ATVB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MIunder65 Exclusive	ATVB	0.51	0.87	0.78	0.50	0.01
ATVB Exclusive	UKB-MIunder65	0.53	1.84	1.60	1.15	1.31
UKB-MIunder65 Exclusive	ATVB Exclusive	0.51	1.06	1.03	0.42	0.27
ATVB Exclusive	UKB-MIunder65 Exclusive	0.52	1.29	1.98	1.26	1.07
UKB-MIunder65 Exclusive	Overlap	0.43	-0.53	-0.64	-0.77	-0.48
ATVB Exclusive	Overlap	0.62	0.99	1.04	0.68	1.02
Overlap	Exclusives	0.49	-0.59	-0.72	-0.84	-0.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MIunder65 Exclusive	ATVB	0.01	0.13	0.27	-0.09	-0.34
ATVB Exclusive	UKB-MIunder65	0.01	0.27	0.23	-0.08	-0.05
UKB-MIunder65 Exclusive	ATVB Exclusive	0.01	0.39	0.36	-0.17	-0.20
ATVB Exclusive	UKB-MIunder65 Exclusive	0.01	-0.04	0.31	-0.03	-0.01
UKB-MIunder65 Exclusive	Overlap	0.00	-0.65	-0.51	-0.39	-0.55
ATVB Exclusive	Overlap	0.00	0.25	-0.06	-0.08	-0.13
Overlap	Exclusives	0.02	-0.50	-0.50	-0.72	-0.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-MIunder65 Exclusive	225	213	CCDC111;DNAJC25-GNG10;8-Sep;FAM203A;C3orf35;KIAA1967;C9orf96;2-Mar;ANKHD1-EIF4EBP3;PRAMEF11;LOC402160;CXCR7
ATVB Exclusive	113	108	ZNF23;GPER;ADC;SELRC1;LOC729020
Overlap	4	4