Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	GeneGroup2	2.35e-02	2.51e-01	2.49e-09	3.54e-15
GeneGroup2	GeneGroup1	3.25e-01	8.05e-01	8.14e-01	6.41e-01



Evaluating how well GeneGroup1 genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GeneGroup2	0.66	0.25	0.57	-0.02	6.94
GeneGroup2	GeneGroup1	0.53	-0.72	0.23	-0.54	0.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GeneGroup2	0.01	-0.06	-0.43	-0.21	2.47
GeneGroup2	GeneGroup1	0.00	-1.05	-0.04	-0.66	-0.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	13	13	
GeneGroup2	212	156	MIR141;MIR7704;MIR151A;MIR409;MIR1307;MIR204;MIR939;MIR6803;CBS;COX2;MIR1301;MIR200A;MIR3173;MIR1306;MIR222;MIR1228;MIR8061;MIR1296;MIR432;MIR375;MIR215;MIR483;MIR744;MIR1260B;MIR2116;MIR1260A;MIR487B;MIR205;MIR4482;MIR17HG;MIR33B;MIR221;MIR6741;MIR628;FAM234A;MIR98;MIR485;MIR30A;MIR144;MIR4516;MIR203A;MIR339;MIR885;MIRLET7D;ND1;MIR92B;MIR214;MIR27A;MIR127;MIR1249;MIR1226;MIR181C;MIR335;MIR10B;MIR377;MIR1908