Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI_Control	ViralGS	4.90e-02	7.85e-05	1.01e-01	4.18e-11
ViralGS	EPI_Control	1.12e-01	7.03e-01	1.37e-01	5.05e-01



Evaluating how well EPI_Control genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_Control	ViralGS	0.70	1.09	3.95	1.35	6.91
ViralGS	EPI_Control	0.48	0.79	-0.42	-0.34	-0.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_Control	ViralGS	0.01	0.49	4.59	0.51	5.86
ViralGS	EPI_Control	0.01	1.98	0.38	-0.03	0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI_Control	105	100	RECQL4;CSNK2A3;2-Mar;LOC100130301;RMDN1
ViralGS	108	104	HLA-DRB4;SNORA31;MBL3P;ABO