Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_Control	ViralGS	5.18e-01	6.47e-01	6.90e-01	1.21e-07
ViralGS	EAML_Control	7.46e-01	7.13e-01	3.60e-01	5.69e-01



Evaluating how well EAML_Control genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_Control	ViralGS	0.64	-0.44	-0.69	-0.02	5.36
ViralGS	EAML_Control	0.50	0.70	-0.47	0.38	-0.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_Control	ViralGS	0.01	-0.29	0.87	-0.01	3.17
ViralGS	EAML_Control	0.00	0.24	-0.17	0.22	-0.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_Control	29	27	CSNK2A3;RMDN1
ViralGS	108	104	HLA-DRB4;MBL3P;SNORA31;ABO