Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_Control	CovidGS	4.42e-01	4.68e-01	4.57e-01	4.82e-07
CovidGS	EAML_Control	6.18e-01	4.51e-01	6.51e-01	3.18e-01



Evaluating how well EAML_Control genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_Control	CovidGS	0.65	-0.53	-0.87	-0.51	5.09
CovidGS	EAML_Control	0.47	-0.17	-1.32	-0.15	-0.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_Control	CovidGS	0.01	-0.49	-0.37	-0.44	3.40
CovidGS	EAML_Control	0.00	-0.29	-0.24	-0.22	-0.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_Control	29	27	CSNK2A3;RMDN1
CovidGS	78	75	MBL3P;ABO;HLA-DRB4