Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet_Control Exclusive	CovidGS	3.72e-02	2.39e-01	5.49e-16	1.60e-09
CovidGS Exclusive	Wavelet_Control	4.29e-05	1.31e-03	6.18e-10	2.98e-25
Wavelet_Control Exclusive	CovidGS Exclusive	2.12e-02	2.09e-01	1.39e-15	2.77e-09
CovidGS Exclusive	Wavelet_Control Exclusive	2.42e-05	1.38e-03	9.08e-10	9.13e-24
Wavelet_Control Exclusive	Overlap	1.37e-01	3.23e-01	7.88e-02	1.41e-01
CovidGS Exclusive	Overlap	1.38e-03	1.68e-03	1.38e-03	1.85e-03
Overlap	Exclusives	7.44e-05	1.26e-04	1.88e-76	2.38e-44



Evaluating how well Wavelet_Control genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet_Control Exclusive	CovidGS	0.75	2.17	2.05	1.86	7.86
CovidGS Exclusive	Wavelet_Control	0.77	-1.72	4.36	3.26	12.76
Wavelet_Control Exclusive	CovidGS Exclusive	0.75	2.35	2.39	1.73	7.66
CovidGS Exclusive	Wavelet_Control Exclusive	0.76	-1.85	4.68	2.55	11.40
Wavelet_Control Exclusive	Overlap	0.77	-0.98	-0.62	-0.12	1.79
CovidGS Exclusive	Overlap	0.99	5.14	2.45	2.76	2.69
Overlap	Exclusives	0.77	2.47	4.55	1.17	12.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet_Control Exclusive	CovidGS	0.01	2.47	-0.36	2.34	10.66
CovidGS Exclusive	Wavelet_Control	0.02	-2.36	5.81	4.00	11.09
Wavelet_Control Exclusive	CovidGS Exclusive	0.01	3.39	0.56	1.83	15.06
CovidGS Exclusive	Wavelet_Control Exclusive	0.02	-2.27	4.75	2.85	14.40
Wavelet_Control Exclusive	Overlap	0.00	-1.14	-1.47	-0.62	0.29
CovidGS Exclusive	Overlap	0.01	1.21	9.99	12.33	9.76
Overlap	Exclusives	0.03	4.21	9.91	1.85	20.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet_Control Exclusive	160	160	
CovidGS Exclusive	75	72	ABO;HLA-DRB4;MBL3P
Overlap	3	3