Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2MethodControls	ViralGS	6.00e-01	4.73e-01	3.77e-02	3.51e-07
ViralGS	2MethodControls	4.26e-01	8.83e-01	1.30e-01	1.99e-01



Evaluating how well 2MethodControls genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2MethodControls	ViralGS	0.65	-0.08	-0.23	-0.06	5.80
ViralGS	2MethodControls	0.56	-0.03	-0.28	0.58	1.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2MethodControls	ViralGS	0.01	-0.30	-0.53	-0.20	1.88
ViralGS	2MethodControls	0.00	-0.16	-0.12	0.52	0.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2MethodControls	37	35	CSNK2A3;RMDN1
ViralGS	108	104	ABO;MBL3P;SNORA31;HLA-DRB4