Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2MethodControls	CovidGS	2.89e-01	1.78e-01	1.62e-02	1.64e-06
CovidGS	2MethodControls	2.68e-01	7.86e-01	2.22e-01	3.44e-01



Evaluating how well 2MethodControls genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2MethodControls	CovidGS	0.67	0.05	0.11	0.12	4.65
CovidGS	2MethodControls	0.54	-1.10	-0.84	-0.06	0.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2MethodControls	CovidGS	0.01	-0.37	-0.77	-0.20	2.79
CovidGS	2MethodControls	0.00	-0.62	-0.21	0.14	0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2MethodControls	37	35	CSNK2A3;RMDN1
CovidGS	78	75	HLA-DRB4;MBL3P;ABO