Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-MI_FDR05 Exclusive	ATVB_FDR1	2.76e-01	6.59e-01	1.50e-01	5.48e-01
ATVB_FDR1 Exclusive	UKB-MI_FDR05	5.28e-01	2.83e-01	3.67e-01	2.46e-01
UKB-MI_FDR05 Exclusive	ATVB_FDR1 Exclusive	2.84e-01	5.59e-01	1.22e-01	4.59e-01
ATVB_FDR1 Exclusive	UKB-MI_FDR05 Exclusive	3.64e-01	3.12e-01	3.51e-01	1.96e-01
UKB-MI_FDR05 Exclusive	Overlap	3.20e-01	3.67e-01	2.40e-01	7.14e-01
ATVB_FDR1 Exclusive	Overlap	9.92e-02	9.92e-02	1.41e-01	1.57e-01
Overlap	Exclusives	1.35e-02	8.80e-01	2.96e-14	8.84e-01



Evaluating how well UKB-MI_FDR05 genes are linked to ATVB_FDR1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI_FDR05 Exclusive	ATVB_FDR1	0.48	-0.65	-0.69	-0.74	-0.75
ATVB_FDR1 Exclusive	UKB-MI_FDR05	0.47	-0.63	-1.25	-0.76	-1.30
UKB-MI_FDR05 Exclusive	ATVB_FDR1 Exclusive	0.48	-0.64	-0.80	-0.84	-0.71
ATVB_FDR1 Exclusive	UKB-MI_FDR05 Exclusive	0.46	-0.85	-1.25	-0.68	-1.44
UKB-MI_FDR05 Exclusive	Overlap	0.41	-0.75	-0.99	-0.99	-0.20
ATVB_FDR1 Exclusive	Overlap	0.93	1.98	1.79	1.60	1.33
Overlap	Exclusives	0.49	-0.16	-0.29	-0.21	-0.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-MI_FDR05 Exclusive	ATVB_FDR1	0.01	13.70	16.11	7.30	11.56
ATVB_FDR1 Exclusive	UKB-MI_FDR05	0.01	0.28	0.05	0.24	-0.32
UKB-MI_FDR05 Exclusive	ATVB_FDR1 Exclusive	0.01	15.47	13.01	16.86	14.13
ATVB_FDR1 Exclusive	UKB-MI_FDR05 Exclusive	0.01	0.26	-0.15	0.19	-0.32
UKB-MI_FDR05 Exclusive	Overlap	0.00	-0.53	-0.71	-0.31	-0.27
ATVB_FDR1 Exclusive	Overlap	0.00	5.32	6.99	1.83	-0.07
Overlap	Exclusives	0.01	0.18	0.45	-0.14	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-MI_FDR05 Exclusive	136	134	CENPC1;ARIH2OS
ATVB_FDR1 Exclusive	116	111	ADC;LOC729020;ZNF23;SELRC1;GPER
Overlap	1	1