Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveletControls	JLC	2.46e-01	1.04e-01	1.16e-04	3.01e-03
JLC	WaveletControls	1.19e-04	1.86e-02	3.90e-04	9.09e-33



Evaluating how well WaveletControls genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveletControls	JLC	0.82	1.61	3.20	1.37	3.10
JLC	WaveletControls	0.79	1.88	3.20	1.56	14.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveletControls	JLC	0.00	2.31	4.24	1.70	2.33
JLC	WaveletControls	0.02	4.04	3.77	3.36	15.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveletControls	163	163	
JLC	13	10	UNC93B;TRIF;NEMO