Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	JLC	3.17e-02	6.50e-01	8.73e-02	2.52e-01
JLC	GeneGroup1	1.42e-02	7.39e-01	4.77e-01	1.33e-02



Evaluating how well GeneGroup1 genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	JLC	0.58	-0.44	-0.39	-0.45	1.02
JLC	GeneGroup1	0.54	0.01	-0.67	-0.29	1.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	JLC	0.00	-0.61	-0.37	-0.58	-0.19
JLC	GeneGroup1	0.01	-0.23	-1.01	-0.37	-0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	101	101	
JLC	13	10	TRIF;UNC93B;NEMO