Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPIControls	JLC	4.24e-01	8.63e-01	5.40e-01	3.31e-01
JLC	EPIControls	1.04e-02	7.28e-02	5.82e-02	3.98e-02



Evaluating how well EPIControls genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPIControls	JLC	0.61	-0.36	0.14	-0.10	1.25
JLC	EPIControls	0.47	0.70	-1.18	-0.08	-0.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPIControls	JLC	0.00	-0.63	-0.31	-0.33	-0.08
JLC	EPIControls	0.01	0.37	-0.46	-0.12	-0.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPIControls	105	100	RMDN1;LOC100130301;2-Mar;RECQL4;CSNK2A3
JLC	13	10	NEMO;TRIF;UNC93B