Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAMLControls	JLC	2.17e-01	7.22e-01	3.64e-01	4.38e-01
JLC	EAMLControls	3.82e-02	1.45e-01	3.20e-01	4.84e-01



Evaluating how well EAMLControls genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAMLControls	JLC	0.57	-1.06	-1.33	-0.72	0.82
JLC	EAMLControls	0.44	-1.00	-2.04	-0.94	-1.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAMLControls	JLC	0.00	-0.51	-0.93	-0.54	-0.25
JLC	EAMLControls	0.00	-0.53	-0.21	-0.66	-0.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAMLControls	29	27	RMDN1;CSNK2A3
JLC	13	10	UNC93B;TRIF;NEMO