Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SevereSingletons	CovidGS	3.12e-01	2.23e-01	1.88e-01	6.64e-07
CovidGS	SevereSingletons	3.33e-01	8.78e-01	1.07e-01	1.22e-01



Evaluating how well SevereSingletons genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SevereSingletons	CovidGS	0.67	-0.01	2.43	0.05	4.82
CovidGS	SevereSingletons	0.57	0.97	0.27	-0.12	1.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SevereSingletons	CovidGS	0.01	-0.41	2.22	-0.29	2.61
CovidGS	SevereSingletons	0.00	0.45	-0.15	-0.35	0.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SevereSingletons	69	67	CTSV;NLRC3
CovidGS	78	75	ABO;MBL3P;HLA-DRB4