Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SevereSingletons	JLC	4.98e-01	1.63e-01	4.48e-01	6.01e-02
JLC	SevereSingletons	2.68e-03	5.92e-01	3.14e-01	1.45e-01



Evaluating how well SevereSingletons genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SevereSingletons	JLC	0.70	0.43	1.79	0.60	2.42
JLC	SevereSingletons	0.56	0.07	-0.14	-0.44	1.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SevereSingletons	JLC	0.00	-0.08	1.88	0.01	0.61
JLC	SevereSingletons	0.00	0.37	0.04	-0.13	0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SevereSingletons	69	67	NLRC3;CTSV
JLC	13	10	NEMO;UNC93B;TRIF